Journal article
Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: A factor mixture modelling approach
J Tillmann, M Uljarevic, D Crawley, G Dumas, E Loth, D Murphy, J Buitelaar, T Charman, J Ahmad, S Ambrosino, B Auyeung, S Baumeister, C Beckmann, T Bourgeron, C Bours, M Brammer, D Brandeis, C Brogna, Y De Bruijn, B Chakrabarti Show all
Molecular Autism | BMC | Published : 2020
Abstract
Background: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intrinsically in their severity along continuous factor scores. We also investigated sensory subgroups in relation to clinical variables: sex, age, IQ, social-communication symptoms, restricted and repetitive behaviours, adaptive functioning and symptoms of anxiety and attention-deficit/hyperactivity disorder. Methods: Three hundred thirty-two children a..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 777394 for the project AIMS2-TRIALS. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI. This work was also supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union's Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies' in-kind contributions and from Autism Speaks.